Microsatellite null alleles in parentage analysis
نویسندگان
چکیده
منابع مشابه
STR null alleles complicate parentage testing in South Africa.
BACKGROUND Null alleles complicate parentage testing because they do not contribute positively to phenotypes.Objectives. To survey South African populations for null alleles at short tandem repeat (STR) loci used in parentage testing. METHODS Paternity case data were scanned for apparent contradictions compared with Mendelian inheritance that could be due to null alleles. Estimates of null al...
متن کاملMicrosatellite null alleles and estimation of population differentiation.
Microsatellite null alleles are commonly encountered in population genetics studies, yet little is known about their impact on the estimation of population differentiation. Computer simulations based on the coalescent were used to investigate the evolutionary dynamics of null alleles, their impact on F(ST) and genetic distances, and the efficiency of estimators of null allele frequency. Further...
متن کاملParentage Tests in Khuzestan Buffaloes Populations Using Three Microsatellite Markers
Pedigree information and phenotypic records are the key features in animal genetics and breeding. Otherwise best methods for genetic evaluation and estimation of parameters will be tending to no correct results. This study was aimed to investigate and verify pedigree relations among 76 individuals who were genotyped for 3 fluorescent labeled microsatellite markers picked up from FAO-ISAG joint ...
متن کاملParentage Tests in Khuzestan Buffaloes Populations Using Three Microsatellite Markers
Pedigree information and phenotypic records are the key features in animal genetics and breeding. Otherwise best methods for genetic evaluation and estimation of parameters will be tending to no correct results. This study was aimed to investigate and verify pedigree relations among 76 individuals who were genotyped for 3 fluorescent labeled microsatellite markers picked up from FAO-ISAG joint ...
متن کاملFunctional analysis of human RPS14 null alleles.
Previously we described a large collection of cloned human DNAs that encode chemically defined missense mutations within the ribosomal protein S14 sequence. We determined that biologically inactive (i.e. null) alleles resulted primarily from point mutations targeted to two internal segments of the S14-coding sequence and designated these functionally critical regions as domains B and D. Further...
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ژورنال
عنوان ژورنال: Heredity
سال: 2004
ISSN: 0018-067X,1365-2540
DOI: 10.1038/sj.hdy.6800545